Nevertheless, a previous study conducted between March 2, 2007 and December 21, 2015 has demonstrated that oral insulin at a dose of 7.5 mg/d, compared with a placebo, did not delay or prevent the development of T1D over 2.7 years in autoantibody-positive relatives of T1D patients (54). The gene discussed is INS; the disease is type 1 diabetes mellitus.