In this study, we investigated a subset of this EOPD cohort for CNVs and non-coding variants that could potentially result in the dysregulated expression of RAB39B. Although the non-coding variants may not directly impact protein function, they can alter the protein levels in neurodegenerative diseases such as PD by modulating mRNA synthesis, stability, localization, and translation. The gene discussed is RAB39B; the disease is neurodegenerative disease.