These experimental test systems include cytokine and Aβ42-peptide stressed human neuronal–glial (HNG) cells in primary co-culture, transgenic murine models for AD (TgAD; including the amyloid over-expressing 5xFAD TgAD model carrying 5 familial AD mutations), and in AD and PrD themselves (2, 11, 12, 14, 24–26, 31, 34). This evidence concerns the gene PEPD and Alzheimer disease.