Currently, there is (i) considerable research effort involving miRNA-based pre-symptomatic predictive and/or diagnostic biomarkers in the cerebrospinal fluid (CSF) and blood serum of the systemic circulation; and (ii) related therapeutic opportunities that address a wide range of these insidious, progressive, and lethal neurological disorders in which signaling along the NF-kB–miRNA-146a axis appears to be playing a critical role in brain cell fate (8, 9, 24, 56). Here, NFKB1 is linked to nervous system disorder.