In a similar model, but in case of variants in the CNR1 gene encoding the endocannabinoid 1 receptor and the GABRA6 gene encoding the alpha 6 subunit of the GABA-A receptor we found that not only the certain genes mediate only certain types of life events which is different in case of different genes, but also that in case of the same genetic variant, the affected outcome phenotype (in our study depression vs anxiety) may also be different in case of different types of recent stress (45). The gene discussed is PSMA1; the disease is major depressive disorder.