TNFRSF1B and chronic kidney disease: In the CKD in Children (CKiD) multicenter cohort center, plasma concentrations of proximal tubular injury (kidney injury molecular-1, KIM-1), pro-inflammatory markers (monocyte chemoattractant protein-1, MCP-1) and receptors for proinflammatory markers (tumor necrosis factor alpha; TNFR1 and TNFR2) in the highest quartile identified children at greater risk of CKD progression compared with those with concentrations in the lowest quartile (Greenberg et al., 2020).