LEP signaling was implicated in a number of processes in the domestic chicken, including glucose and insulin activity (Kamohara et al., 1997; German et al., 2009; Huo et al., 2009), with hyperglycemia downregulating LEPR and insulin receptor (INSR; Rancourt et al., 2015). The gene discussed is INSR; the disease is Hyperglycemia.