LMNA and Ventricular arrhythmia: However, human DCM is an autosomal-dominant disease and, therefore, heterozygous mice for Lmna+/- have been further evaluated and which demonstrate atrioventricular (AV) conduction defects, atrial and ventricular arrhythmia, and at an advanced age also impaired cardiac contractility, which mimics haploinsufficiency of human disease (Wolf et al., 2008).