PLN and familial dilated cardiomyopathy: Although many human mutations have been described to cause DCM, an in-frame 3-bp deletion mutation leading to removal of R14 in phospholamban has been reported to cause both DCM and ACM, indicating the clinical overlap of both cardiomyopathies in particular for this mutation (van der Zwaag et al., 2012; Fish et al., 2016).