Some studies have described an overexpression of the RAGE in the placenta and maternal serum in cases of pPROM and also a progressive increase of the soluble isoform of RAGE (sRAGE), acting as a decoy, during pregnancy and then finally decreasing at term (Romero et al., 2008; Yan et al., 2018). This evidence concerns the gene AGER and preterm premature rupture of the membranes.