CASP3 and kidney injury: However, according to a preclinical study in rodents, this might be related to the observation of a low cleaved caspase-3 level as a measure of apoptosis, a low level of tubular necrosis, low interleukin (IL)-6 messenger RNA (mRNA) levels (a pro-inflammatory cytokine that has been found in kidney injury), but a significant increase in infiltrating macrophages who play role in repair response post-injury in a high-frequency low-dose cisplatin regimen (Sharp et al., 2016).