ATF3 and myocardial infarction: Furthermore, the RNA-seq matrix of myocardial infarction tissue in 20 mice was screened from the GEO database (GSE23294), then the differential expression analysis was performed to further verify the expression of ATF3 and JUN. The results suggested that ATF3 and JUN were both downregulated in heart damage tissue of mouse and human (Table 5).