NR1H4 and cholestasis: Moreover, it is known that cholestasis is caused by the imbalance of bile acids regulation, and Farnesoid X receptor (FXR) plays an important role in bile acids regulation, inhibition of FXR can augment the accumulation of bile acids in the liver, and subsequently cause liver injury (Guo et al., 2016; Shin and Wang, 2019), T-βMCA is a natural antagonist of FXR (Takahashi et al., 2016), the correlation analysis showed that T-βMCA were positively correlated with ALT (Figure 9), implying that suppressed FXR was a key factor in OA hepatotoxicity, but further study is needed to confirm.