Moreover, SUMO1 is also associated with lysosomal remnants in glial cytoplasmic inclusions of Multiple System Atrophy (MSA) brains (Pountney et al., 2005; Wong et al., 2013; Radford et al., 2014), and SUMO1 is found by confocal microscopy to co-localize with both α-synuclein and HSP90 in the disease inclusions (Wong et al., 2013). This evidence concerns the gene SUMO1 and multiple system atrophy.