Overall, although SUMO1 covalent conjugation to α-synuclein in α-synucleinopathy lesions need to be confirmed by improved mass spectrometry techniques, the current findings suggest that different proteins present in α-synucleinopathy lesions, including α-synuclein (Rott et al., 2017) and HSP90 (Uryu et al., 2006), could be SUMOylated and could also play a role in neurodegeneration. This evidence concerns the gene SUMO1 and synucleinopathy.