SUMOylation also increases the levels of tau, huntingtin, ataxin-3 and SOD1 (Fei et al., 2006; O’Rourke et al., 2013; Zhou et al., 2013; Luo et al., 2014; Ochaba et al., 2016), supporting a broader role of SUMOylation in neurodegenerative diseases. The gene discussed is MAPT; the disease is neurodegenerative disease.