Since the AGD cases used for inoculation do not contain 3Rtau deposits, and the western blotting of sarkosyl-insoluble fractions shows a typical signature of 4Rtaupathy, the presence of 3Rtau implies the necessary phosphorylation of murine 3Rtau, in addition to 4Rtau, in the composition of abnormal tau deposits in mice inoculated with AGD sarkosyl-insoluble fractions. The gene discussed is MAPT; the disease is argyrophilic grain disease.