The morphological characteristics of tau deposits in neurons, as revealed with phospho-specific anti-tau antibodies, are similar to those seen in human AGD cases bearing only pre-tangles; threads and dots are also similar to those seen in AGD, but their presence in the corpus callosum indicates that most “grains” in inoculated mice are not located in dendrites, in contrast to the ordinary dendritic localization of grains in AGD (Ferrer et al., 2008). This evidence concerns the gene MAPT and argyrophilic grain disease.