Our previous studies have shown tau seeding and spreading following inoculation of sarkosyl-insoluble fractions from AD, primary age-related tauopathy (PART), aging-related tau astrogliopathy (ARTAG), progressive supranuclear palsy (PSP), Pick’s disease (PiD), frontotemporal lobar degeneration linked to MAPT P301L mutation, and sporadic and familial globular glial tauopathy (GGT) into the hippocampus and corpus callosum of WT mice (Ferrer et al., 2018, 2019, 2020a,b). This evidence concerns the gene MAPT and Pick disease.