Tau seeding and spreading occur following unilateral inoculation of sarkosyl-insoluble fractions from AD, PART, ARTAG, PSP, PiD, FTLD linked to MAPT P301L mutation, and GGT in the hippocampus of WT mice using the protocol utilized in the present study (Ferrer et al., 2018, 2019, 2020a,b). This evidence concerns the gene MAPT and Alzheimer disease.