As shown in Figures 6A–D, IRP2 and DMT1 were upregulated after 6-OHDA treatment compared with those in the PC12 cells and SN of rats in the control group (Rats IRP2: sham group, 0.49 ± 0.03; PD group, 0.71 ± 0.06; P = 0.0010. Here, IREB2 is linked to Parkinson disease.