P53 is well-known for its tumor-suppressing role which also can be ubiquitinated and degradation by various ubiquitin ligases, such as murine double minute 2, coat protein 1, p53-induced protein with a RING-H2 domain and ARF-binding protein 1 (ARF-BP1) in tumor tissues [46–49]. Here, TP53 is linked to neoplasm.