As shown in Figure 4A, B, the serum of early LC patients with anti-TIF1γ-IgA (+) and anti-TIF1γ-IgG (+) detected by ELISA only bound to the target protein, and not to GST protein; the serum of LBL patients and HC with anti-TIF1γ-IgA(-) and anti-TIF1γ-IgG (-) detected by ELISA did not bind to the target protein or GST protein. This evidence concerns the gene CD79A and laryngotracheoesophageal cleft.