We found that the rate of genetic change in most MMPs was shallow in TCGA-PRAD patients, while the genetic alteration rate of MMP16 is high to 2.6% (Figure 1C), however, when we compared the mRNA expression of MMP16 in different genetic alteration subgroups, there was no difference, of which means that the genetic alteration of MMP16 does no effect to the mRNA expression (Figure 1D). The gene discussed is MMP16; the disease is prostate adenocarcinoma.