We could see that about half MMPs are highly expressed in tumor tissues as compared with normal tissues, including MMP9, MMP10, MMP11, MMP12, MMP15, MMP25, MMP26 (all, P<0.05), while some other MMPs decreased in tumor tissues, including MMP2, MMP14, MMP16, MMP24, MMP28(all, P<0.05). The gene discussed is MMP12; the disease is neoplasm.