The results indicated that the immune dysfunction of narcolepsy is associated not only with abnormal antigen recognition and cross-reaction, as indicated by the association of the HLA-DQB1*06:02 and TRA with narcolepsy risk 13, 20, 47, but also with the dysfunction of IFNAR1 immune-modulation and anti-viral processes. The gene discussed is HLA-DQB1; the disease is narcolepsy.