Since TNF-JNK signaling hyperactivation induces Zfh-1 expression in normal, nutrient-supply condition12, we propose that Egr induced by starvation “primes” cyst cells for Zfh-1 expression upon nutrient resupply, promoting CySC recovery and ectopic Zfh-1 expression in cyst lineage cells during protein refeeding. The gene discussed is MAPK8; the disease is cyst.