RYR2 and cyclic hematopoiesis: We also found that store-operated Ca2+ entry (SOCE) was largely enhanced in PASMCs from CH mice, and CH-induced SOCE was almost completely inhibited in cells from RyR2−/− mice (165 ± 30 vs 987 ± 125 nM, P < 0.05) (Fig. 1f).