RYR2 and cyclic hematopoiesis: Furthermore, PDTC blocked the elevated RVSP in CH mice compared with control animals (28.0 ± 3.0 versus 34.0 ± 4.0 mmHg, P < 0.05), but had no effect in RyR2−/− mice (25.3 ± 3.0 mmHg).