Although the PI3K/AKT signaling pathway was closely related to the genesis and metastasis of some types of tumors, such as colorectal cancer and hepatocellular carcinoma [25, 26], the levels of PI3K/AKT were comparable between the tumoral tissues and para-carcinoma tissue from BC patients with clinical stages (Figure 5A). The gene discussed is AKT1; the disease is colorectal cancer.