EGFR and adenocarcinoma: In multivariate K-M plots of EGFR-mutant NSCLC patients, we found a significant difference in OS between EGFR-mutant and wild-type individuals in the total population (HR, 0.82; 95% confidence interval (CI), 0.70 to 0.97), restricted to males (HR, 0.74; 95% CI, 0.60 to 0.91), stage I NSCLC (HR, 0.43; 95% CI, 0.30 to 0.60) and adenocarcinoma (HR, 0.78; 95% CI, 0.61 to 1.00) (Supplementary Figure 5).