During the acute phase of infection, the T. gondii protein profilin is recognized by the MyD88-dependent signaling pathway through recognition by TLR11 and TLR12 (4, –, 6), which are expressed by CD8α+ conventional dendritic cells (cDCs) and tissue-resident CD103+ cDCs (7), as well as macrophages and epithelial cells (8). The gene discussed is CD8A; the disease is infection.