RAG1 and neoplasm: To evaluate the impact of OT1-iT cells on B16F10-OVA tumor proliferation in OT1-iT-Rag1-/- mice, B16F10-OVA tumor cells were subcutaneously injected into OT1-iT-Rag1-/- mice 6 weeks’ post-transplantation (figure 3A).