Moreover, proinflammatory cytokines are found to be associated with the progression of cerebral white matter injury (WMI) in preterm infants, and cytokine-receptor interaction may be critical in determining the effects of inflammation in the development of the disease, which further suggested that CXCR2 might have been related to the development of psoriasis via the chemokine signaling pathway and cytokine-cytokine receptor interaction. The gene discussed is CXCR2; the disease is psoriasis.