The IC50 of cisplatin decreased in PLC/PRF/5 (5.60 ± 0.70 versus 15.30 ± 0.35, P < 0.001) and Hep3B (5.45 ± 0.24 versus14.05 ± 0.49, P < 0.001) cells after THOC1 knockdown compared with siNC transfection, indicating that the knockdown of THOC1 can sensitize HCC cells to cisplatin (Fig. 3e). This evidence concerns the gene THOC1 and hepatocellular carcinoma.