In addition, we directly showed the lethal effects of JQ1 and dBET6 at the same concentrations and compared the results to depletion of ASXL3 and BRD4 in the ASXL3 high (NCI-H1963) versus ASXL3 low (NCI-H2171) SCLC cells (Additional file 2: Figure S6G). This evidence concerns the gene BRD4 and small cell lung carcinoma.