TNFRSF1B and neoplasm: Using anti-TNFR2 treatment could be an efficient way to simultaneously hamper immunosuppression by T regs [38, 69] and other immunosuppressive cells present in the tumor microenvironment [70], to directly eliminate TNFR2 expressing tumor cell [71, 72], to interrupt angiogenesis [73], and to decrease MSC survival and function.