HNF4A and colorectal carcinoma: In particular, at low micromolar concentrations (1–5 μM), ivermectin suppressed the expression of Wnt-TCF targets, such as AXIN2, LGR5 and ASCL2 in DLD1 and Ls174T CRC cell lines and blocked colon cancer stem cell self-renewal in a clonogenic assay [49].