In detail, in HCT-116 and DLD1 CRC cells, rafoxanide (1.25–5 μM) induced autophagy and all the main damage-associated molecular patters (DAMPs) (ecto-calreticulin exposure, adenosine triphosphate (ATP)/high mobility group box 1 (HMGB1) release) required for ICD. Here, HMGB1 is linked to colorectal carcinoma.