TP53 and cancer: Functional pathway analysis of mRNAs targeted by CUSA-EV miRNAs (212 species DE in GBM relative to GII-III; p ≤ 0.05) showed clear associations to the GBM signaling pathway (Figure S2) and more broadly, ‘molecular mechanisms of cancer.’ Significant links to IL-6 inflammatory pathways and p53 signaling which play important roles in gliomagenesis [63,64,65,66] were also observed, as well as functional associations to tumor morphology, cell growth, proliferation and cellular movement that are pertinent features of highly infiltrative and aggressive GBMs.