Paradoxically, other studies have reported that increased miR-486-3p expression promotes chemo-sensitivity of GBM to TMZ by targeting MGMT [94] and esophageal carcinoma cell-lines to 5-fluorouracil [95], suggesting important roles for miR-486-3p in targeting cell survival molecular pathways in response to cytotoxic stimuli. Here, MGMT is linked to glioblastoma.