Several clinical trials investigating the clinical efficacy of anakinra (IL-1R antagonist), siltuximab (anti IL-6 antibody that binds IL-6 prevents the binding of IL-6 to both soluble and membrane-bound IL-6R, inhibiting IL-6 signaling), tocilizumab and sarilumab (anti IL-6R antibody) in COVID-19 treatment are currently under way [87,88]. The gene discussed is IL6R; the disease is COVID-19.