Inhibition of IL-6 related signalling pathways via blocking IL-6 or IL-6 receptors (IL-6R) is a promising approach to prevent CRS/cytokine storm syndrome and rapid, severe, and serious deterioration during SARS-CoV-2 infection and transition to COVID-19 [6,82,83,84]. The gene discussed is IL6; the disease is congenital rubella syndrome.