RHO and retinal degeneration: Wild-type NR2E3 cDNA was packaged into an AAV8 vector and injected subretinally in various mouse retinal degeneration models; AAV8-Nr2e3 treatment at P0 preserved ONL photoreceptor density, increased green and blue opsin+ and rhodopsin+ cells, and improved ERG response, which the authors attributed to increased recruitment of phototransduction-relevant transcription factors in a number of rodent preclinical models of RP [81].