For the first case a novel glutamine fructose-6-phosphate transaminase 1 (GFPT1)-ALK fusion was detected and the second case held the echinoderm microtubule-associated protein-like 4 (EML4)-ALK fusion, with breakpoints located in intron 13 of EML4 and intron 19 of ALK, which is the most common variant in non-small-cell lung cancer (NSCLC). The gene discussed is ALK; the disease is non-small cell lung carcinoma.