Furthermore, in May 2020 the European Commission (EC) granted conditional approval for onasemnogene abeparvovec for SMA type I patients with a bi-allelic mutation in the SMN1 gene or for SMA patients with a bi-allelic mutation in the SMN1 gene and up to three copies of the SMN2 gene. This evidence concerns the gene SMN2 and proximal spinal muscular atrophy.