On the other side, neurotrophic factors involved in high neuroinflammatory states such as ciliary neurotrophic factor affect food intake and body weight in experimental models of obesity induced by high-fat diet through a mechanism that involves influencing the activity of neuronal circuits and pathways located in the arcuate nucleus of the hypothalamus [58]. Here, CNTF is linked to obesity due to melanocortin 4 receptor deficiency.