For instance, Montalvo et al. [7] showed, in a pressure-overloaded mice model, that myocardial fibrosis was increased in male mice, due to myocardial TGF-β induction by gonadal androgens, which could be prevented by orchidectomy or inhibition of TGF-β. Here, TGFB1 is linked to Myocardial fibrosis.