The most aggressive course is the disseminated form of the disease, in the tissue of the primary tumor of which there is an increase in the content of NF-kB p50 (1.6 times), NF-kB p65 (1.4 times), HIF-1 (5.5 times) and HIF-2 (1.3 times) compared with normal renal parenchyma. Here, NFKB1 is linked to neoplasm.