SMAD3 and non-small cell lung carcinoma: To investigate whether miR-216b can increase BCL-2 expression and promote resistance of lung cancer cells to anti-cancer drugs by downregulating Smad3 expression, we established NCI-H460 human NSCLC cell clones by stably expressing miR-216b using lentiviral vector plenty-III-GFP pri-mir-216b.