As evidenced by VEGFR-2 expression in vitro (Figure 1) and supported by literature results demonstrating a lack of VEGFR-2 expression in HCC tissue stained for the receptor [42,43,44], the cancer cells do not express the receptors of the VEGF circuit, explaining the less pronounced effect seen with in vitro models. The gene discussed is KDR; the disease is hepatocellular carcinoma.