TMEM97 and breast adenocarcinoma: In a pioneer study, our lab demonstrated that the σ2R is a promising biomarker of the proliferative status in cell culture and mouse models with subcutaneous injection of mouse mammary adenocarcinoma line 66 cells, labeling with BrdU over time and assessing the proliferation status using flow cytometry compared to expression of σ2R using radioligand binding assays [12,13].