The metabolic dependency of cancer cells on cholesterol and other lipids is tightly regulated by the cholesterol homeostasis network, including (1) SREBP, master transcriptional regulators of cholesterol and fatty acid pathway genes, (2) nuclear sterol receptors (liver X receptors, LXR), which regulate intracellular cholesterol level through the expression of cholesterol efflux proteins such as ABC transporters and (3) lipid particle receptors, such as LDLR, providing exogenous sterol and lipids to cancer cells. The gene discussed is ABCG2; the disease is cancer.