In conclusion, on the basis of findings from our study that verified miR-203 as an anti-tumor miRNA in CSCC cell line SCL-1, we demonstrated that overexpression of miR-203 significantly promotes cell apoptosis and attenuates proliferation, migration, and invasion of CSCC cell line SCL-1 by targeting PRC1 and blocking the activation of Wnt/β-catenin signaling pathway (Figure S1). This evidence concerns the gene PRC1 and neoplasm.