In order to confirm that these epitopes were truly processed and presented in the context of viral infection, we infected DR1+ (class 2 knockout [KO] C57BL/6) mice with X31, lab-adapted strain of IAV (H3N2) and measured ex vivo IFN-γ ELISpot responses (Figures 2D and 2E). The gene discussed is DR1; the disease is viral infectious disease.