For example, PHGbrown (cluster C) overlaps with mouse brain expression signatures from models of HD (M94, padj = 2.5 × 10−10), FTD-ALS (FUS) (M173, padj = 4.8 × 10−6), SCA1 (M155, padj = 1.5 × 10−18), and CJD (M200, padj = 6.0 × 10−32). Here, FUS is linked to frontotemporal dementia.