To explore targeted proteolysis of K-RAS using the AdPROM system, we used CRISPR/Cas9 technology to generate an A549 non-small cell lung carcinoma (NSCLC) cell line harboring a homozygous knockin of green fluorescent protein (GFP) cDNA at the N terminus of the native K-RAS gene (Figure S1). The gene discussed is KRAS; the disease is non-small cell lung carcinoma.