MAVS and infection: Although a MAVS cleavage product was not detected during FMDV infection, densitometry analysis revealed a strong and progressive decrease in the relative ratio of MAVS/tubulin from 2–6 hpi post infection with wt FMDV compared to mock-infected cells, whereas only a small decrease was detected in leaderless-infected cells (MAVS/tubulin ratio is indicated in Fig 3A).