For instance, the antiparasitic pyrimethamine or the antipsychotic pimozide have been shown to, respectively, inhibit the phosphorylation of STAT3 and STAT5 in different haematopoietic cancers, whereas the antidiabetic drug pioglitazone was found to reduce STAT5A and STAT5B gene expression in CML cells.21, 31, 32. This evidence concerns the gene STAT5A and chronic myelogenous leukemia, BCR-ABL1 positive.