Currently, no cure or disease-modifying treatment is available for Alzheimer disease, and recent attempts with novel disease-modifying drugs have been ineffective.39,40,41 The most frequently prescribed treatments for Alzheimer disease are acetylcholinesterase inhibitors and memantine.42 In addition, the current treatments are not effective for everyone; it is estimated that approximately 40% to 70% of patients benefit from current treatments. The gene discussed is ACHE; the disease is early-onset autosomal dominant Alzheimer disease.