BCHE and early-onset autosomal dominant Alzheimer disease: It is possible that the association between dopamine agonists and cholinesterase inhibitors could have masked measurable effects on memory tasks.37 On the other hand, the medial temporal lobe is a site of complex pathological mechanisms linking neurodegeneration with neuroinflammation38 that likely begin long before cognitive decline appears, making the contribution of dopaminergic neurotransmission negligible in patients with moderate Alzheimer disease.