Cytokine storm syndrome is thought to be a major pathogenetic mechanism in multiple organ failure associated with SARS-CoV-2 infection.(18) Indeed, high levels of expression of cytokines and chemokines, such as interleukin-6 (IL-6), have been reported in COVID-19 patients and were found to be positively correlated with disease severity. This evidence concerns the gene IL6 and Multiple Organ Failure.