It is probably explained that diabetic neuropathy is a chronic complication1, 4, 5, 6; therefore, SCs may lose their survivability as a result of the cumulative effect of long standing hyperglycaemia marked by elevated HbA1c, and exogenous neuritin, if given for a certain period and as a single treatment, needs to be dosed up to certain extent to revive the poorly viable diabetic SCs with early apoptosis and promote cell proliferation as shown in our experiment. This evidence concerns the gene NRN1 and Hyperglycemia.