Therefore, neuritin is vital to survival of SCs, diabetic or hyperglycaemic conditions can induce neuritin down‐expression in SCs, and underproduction of neuritin including soluble neuritin secreted to extracellular fluids contributes, to some extent, to compromised survival of SCs of rats with diabetic neuropathy. This evidence concerns the gene NRN1 and diabetic neuropathy.