Bone marrow‐derived and alveolar macrophages from aged mice had higher levels of NLRP3 inflammasome activation and caspase‐1–dependent IL‐1β and IL‐18 production, which contributed to the development of experimental pulmonary fibrosis (Stout‐Delgado et al., 2016). The gene discussed is IL18; the disease is pulmonary fibrosis.