Notably, compared with the effects found in the young mice, the protective effects of the NLRP3 blockade on liver IR injury were more significant in the aged mice, leading to comparable liver IR injury and intrahepatic inflammation in both the young and aged mice post‐IR (Figure 2d‐g, IR: Young NLRP3 siRNA vs. Aged NLRP3 siRNA). This evidence concerns the gene NLRP3 and medical procedure.